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6-Thioguanine, Tocris Bioscience™

Product Code. 18792784
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Anticancer and immunosuppressive agent

Anticancer and immunosuppressive agent often used to treat immune disorders and leukemia. Displays cytotoxic and antineoplastic properties; disrupts cytosine methylation by DNA methyltransferases after incorporation into DNA. Selectively kills BRCA2-defective tumors in a xenograft model. Also facilitates proteasome-mediated degradation of DNA (cytosine-5)-methyltransferase 1 (DNMT1). Also inhibits SARS-CoV papain-like protease (PLpro; IC50 = 5 μM for PLpro deubiquitination activity).
TRUSTED_SUSTAINABILITY

Specifications

CAS 154-42-7
Molecular Formula C5H5N5S
MDL Number MFCD00233553
Quantity 50 mg
Synonym 6-thioguanine, thioguanine, tioguanine, 2-amino-6-mercaptopurine, 6-mercaptoguanine, tioguanin, tabloid, lanvis, 2-amino-6-purinethiol, 2-aminopurine-6-thiol
InChI Key WYWHKKSPHMUBEB-UHFFFAOYSA-N
SMILES NC1=NC(=S)C2=C(N1)N=CN2
IUPAC Name 2-amino-6,7-dihydro-3H-purine-6-thione
Molecular Weight (g/mol) 167.19
PubChem CID 2723601
ChEBI CHEBI:9555
Formula Weight 167.19
Percent Purity >99%
Chemical Name or Material 6-Thioguanine
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