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JAK1 Mouse, Unlabeled, Clone: 73, BD
Mouse Monoclonal Antibody
343.00 € - 675.00 €
Specifications
| Antigen | JAK1 |
|---|---|
| Clone | 73 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15825349
|
BD Biosciences
610231 |
50 μg |
343.00 €
1 set |
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|
15835349
|
BD Biosciences
610232 |
150 μg |
675.00 €
1 set |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
The JAK family of receptor-associated protein kinases is directly involved in interferon (IFN) response pathways. The JAK family contains at least three members: JAK1, JAK2, and Tyk2. Each protein is approximately 130kDa and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among family members. In several human and murine cell lines, JAK1 is rapidly tyrosine phosphorylated in response to IFN-α and IFN-γ. JAK1 is required for the phosphorylation of the transcription factor Stat1 (p91), in response to IFNs-α or IFN-γ. JAK1 is also necessary for the efficient phophorylation of Stat2 (p113) in response to IFN-α and for the phosphorylation of Tyk2 or JAK2 in response to IFNs-α or IFN-γ, respectively.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Specifications
| JAK1 | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG2b κ | |
| Affinity Purified |
| 73 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Canine, Chicken, Frog, Human, Mouse, Rat | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.