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  8. AP 24534, Tocris Bioscience™

AP 24534, Tocris Bioscience™

Product Code. 18075312
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Quantity:
10 mg
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Description

Potent multi-kinase and pan-Bcr-Abl inhibitor

Potent multi-kinase and pan-Bcr-Abl inhibitor. Displays potent activity against cell lines expressing native Bcr-Abl or Bcr-AblT3151 (IC50 values are 0.37 and 2.0 nM respectively); also inhibits other Abl kinase domain mutants at nanomolar potencies. Exhibits inhibitory activity against PDGFRα, c-Src and c-Kit (IC50 values are 1.1, 5.4 and 12.5 nM respectively); potently inhibits FGFR and VEGFR family kinases. Orally active. Identified as targeting human host proteins that interact with SARS-CoV-2.

Chemical Identifiers

CAS 943319-70-8
Molecular Formula C29H27F3N6O
Molecular Weight (g/mol) 532.571
InChI Key PHXJVRSECIGDHY-UHFFFAOYSA-N
Synonym ponatinib, ponatinib ap24534, iclusig, 3-imidazo 1,2-b pyridazin-3-ylethynyl-4-methyl-n-4-4-methylpiperazin-1-yl methyl-3-trifluoromethyl phenyl benzamide, ap24534 ponatinib, iclusig tn, 3-2-imidazo 1,2-b pyridazin-3-yl ethynyl-4-methyl-n-4-4-methylpiperazin-1-yl methyl-3-trifluoromethyl phenyl benzamide, benzamide, 3-2-imidazo 1,2-b pyridazin-3-ylethynyl-4-methyl-n-4-4-methyl-1-piperazinyl methyl-3-trifluoromethyl phenyl, ponatinib usan:inn
PubChem CID 24826799
ChEBI CHEBI:78543
IUPAC Name 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

Specifications

Quantity 10 mg
Formula Weight 532.56
Percent Purity >98%
Chemical Name or Material AP 24534
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