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Tocris Bioscience™ API-2

Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral

Brand:  Tocris Bioscience™ 2151/10

Product Code. 18075472

  • 405.00 € / 10mg

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Description

Description

API-2 is a selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3β and AFX. Induces apoptosis and growth arrest in vitro, preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
Specifications

Specifications

99%
35943-35-2
Triciribine, NSC 154020, TCN
API-2
API-2
1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
Room Temperature
10 mg
M.W. (Observed): 320.31
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