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Tocris Bioscience™ AZD 5248
Potent cathepsin C inhibitor
Brand: Tocris Bioscience™ 7130/1
176.24 EUR valid until 2024-12-16
Use promo code "21630" to get your promotional price.
This item is not returnable.
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Description
AZD 5248 is a potent cathepsin C (also known as dipeptidyl peptidase 1, or DPP1) inhibitor (IC50 values are 44 and 67 nM for human and rat, respectively). In vivo, AZD 5248 inhibition of cathepsin C correlates to the reduction of NSP (neutrophil serine protease) activity measured in rat bone marrow and blood. In rats, quantitative whole-body autoradiography studies demonstrate aortic binding of AZ 5248. This compound is orally bioavailable.Specifications
| 4-Amino-N-[(1S)-1-cyano-2-(4'-cyano[1,1'-biphenyl]-4-yl)ethyl]tetrahydro-2H-pyran-4-carboxamide | |
| 1 mg | |
| C22H22N4O2 |
| 1254318-44-9 | |
| Synthetic Cathepsin Inhibitors | |
| 0.98 |