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BMS 299897, Tocris Bioscience™

Product Code. 18095032
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent γ-secretase inhibitor

Orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Exhibits no Notch toxicity. Brain penetrant.

Specifications

CAS 290315-45-6
Molecular Formula C24H21ClF3NO4S
Quantity 10 mg
Synonym 2-1r-1-4-chlorophenyl sulfonyl 2,5-difluorophenyl amino ethyl-5-fluoro-benzenebutanoic acid, 2-1r-1-4-chlorophenyl sulfonyl 2,5-difluorophenyl amino ethyl-5-fluorobenzenebutanoic acid, 4-2-1r-1-n-2,5-difluorophenyl 4-chlorobenzenesulfonamido ethyl-5-fluorophenyl butanoic acid
InChI Key IZAOBRWCUGOKNH-OAHLLOKOSA-N
SMILES CC(C1=C(C=C(C=C1)F)CCCC(=O)O)N(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
IUPAC Name 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid
Molecular Weight (g/mol) 511.94
PubChem CID 11249248
Formula Weight 511.94
Percent Purity >98%
Chemical Name or Material BMS 299897
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