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β-Catenin Mouse, Unlabeled, Clone: 14, BD
Mouse Monoclonal Antibody
429.00 € - 700.00 €
Specifications
| Antigen | β-Catenin |
|---|---|
| Clone | 14 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15815299
|
BD Biosciences
610153 |
50 μg |
429.00 €
1 set |
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|
15825299
|
BD Biosciences
610154 |
150 μg |
700.00 €
1 set |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
β-Catenin is a 92kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens). Deletions in the cytoplasmic domain of E-Cadherin which eliminate catenin binding also result in a loss of cell adhesion, indicating that this binding is essential for E-Cadherin function. Although the α- and β-Catenins have been cloned, very little is known about their biochemical roles. However a link between β-Catenin and colon cancer has been described. β-Catenin was found to co-immunoprecipitate with the APC tumor suppressor protein in human colorectal tumor cell lines, as well as in human kidney 293 cells. E-Cadherin, however, was not detectable in these complexes. Thus the APC-Catenin complex may be affecting the transmission of contact inhibition signals and/or the regulation of cell adhesion.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Specifications
| β-Catenin | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 14 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Canine, Chicken, Human, Mouse, Rat | |
| Mouse β-Catenin aa. 571-781 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.