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CD279 (PD-1) Monoclonal Antibody (J43), Functional Grade, eBioscience™, Invitrogen™

Armenian Hamster Monoclonal Antibody

2985.00 € - 14910.00 €

Specifications

Antigen CD279 (PD-1)
Clone J43
Concentration 1 mg/mL
Applications Flow Cytometry, Functional Assay
Classification Monoclonal
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17141652
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Affymetrix eBioscience
16-9985-38
5 mg This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
N/A
17121652
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Invitrogen
16-9985-025
25 mg
9640.00 €
25mg
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17131652
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Affymetrix eBioscience
16-9985-050
50 mg This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
N/A
Description

Description

The J43 MAb reacts with mouse PD-1 (programmed death-1), a 55 kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. It is reported that J43 inhibits the binding of mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1/BHK transfected cells. When administrated in vivo, both intact and Fab of J43 are reported to enhance contact hypersensitivity and exacerbate acute GVHD similar to transfer of PD-1-deficient cells. Injection of J43 also exacerbates EAE and NOD diabetes as do specific antibodies to mouse PD-L1 and PD-L2.

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "e;danger signals"e; such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Specifications

Specifications

CD279 (PD-1)
1 mg/mL
Monoclonal
Liquid
RUO
PBS with no preservative; pH 7.2
18566
Primary
4° C
Pdcd1
J43
Flow Cytometry, Functional Assay
Functional Grade
Armenian Hamster
Mouse
Q02242
IgG
Affinity chromatography
Antibody
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Documents

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CD279 (PD-1) Monoclonal Antibody (J43), Functional Grade, eBioscience™, Invitrogen™

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