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CD3 Monoclonal Antibody (17A2), PE-eFluor™ 610, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

140.08 € - 371.00 €

Specifications

Antigen CD3
Clone 17A2
Concentration 0.2 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17184053
View Documents
Affymetrix eBioscience
61-0032-80
25 μg This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
N/A
17194053
View Documents
Invitrogen
61-0032-82
100 μg
371.00 €
100µg
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Description

Description

The 17A2 MAb reacts with the mouse CD3 complex. CD3 subunits gamma, delta and epsilon are required for proper assembly, trafficking and surface expression of the TCR complex. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. Binding of 17A2 to CD3 initiates the intracellular biochemical pathway resulting in cellular activation and proliferation.

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Specifications

Specifications

CD3
0.2 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
12500, 12501, 12502, 12503
Primary
4° C, store in dark, DO NOT FREEZE!
17A2
Flow Cytometry
PE-eFluor 610
Rat
Mouse
P04235, P11942, P22646, P24161
IgG2b κ
Affinity chromatography
Antibody
Videos
SDS
Documents

Documents

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CD3 Monoclonal Antibody (17A2), PE-eFluor™ 610, eBioscience™, Invitrogen™

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