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BB700 Mouse Anti-Human CD56 Clone NCAM16.2 (NCAM16) (RUO)
Mouse monoclonal antibody that specifically binds to human CD56.
Brand: BD Biosciences 566573
This item is not returnable.
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Description
- The NCAM16.2 monoclonal antibody specifically binds to human CD56.
- It recognizes an extracellular immunoglobulin-like domain common to 120, 140, and 180 kDa forms of CD56, also known as the neural cell adhesion molecule (NCAM), NKH1 or MSK39.
- The CD56 antigen is expressed on approximately 10% to 25% of peripheral blood lymphocytes.
- It is present on essentially all resting and activated CD16+ natural killer (NK) lymphocytes and approximately 5% of CD3+ peripheral blood lymphocytes. CD3+ CD56+ T lymphocytes comprise a unique subset of cytotoxic T lymphocytes that mediates non-major histocompatibility complex (MHC)-restricted cytotoxicity.
- CD56 antigen density on NK lymphocytes increases upon cellular activation.
- The CD56 antigen is involved in neuronal homotypic cell adhesion and cell differentiation during embryogenesis.
- CD16+ CD56+ NK cells demonstrate reciprocal transfer of an activation state with dendritic cells.
- The antibody was conjugated to BD Horizon BB700, which is part of the BD Horizon Brilliant™ Blue family of dyes.
- It is a polymer-based tandem dye developed exclusively by BD Biosciences.
- With an excitation max of 485 nm and an emission max of 693 nm, BD Horizon BB700 can be excited by the 488 nm laser and detected in a standard PerCP-Cy™5.5 set (eg, 695/40-nm filter).
- This dye provides a much brighter alternative to PerCP-Cy5.5 with less cross laser excitation off the 405 nm and 355 nm lasers.
Specifications
| CD56 (NCAM-1) | |
| Monoclonal | |
| Brilliant Blue 700 (BB700) | |
| 100 Tests | |
| Secondary | |
| Human | |
| IgG2b κ |
| Flow Cytometry | |
| NCAM16.2 (also known as NCAM 16) | |
| Mouse | |
| RUO | |
| CD56 (NCAM-1) | |
| Refrigerate (2 to 8°C) |