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DiscoverX ChemiBrite™ FSH Glycoprotein Hormone Receptor Stable Cell Line

Product Code. 17325329
Encompass
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17325329

Brand: DiscoverX HTS178L

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This item is not returnable. View return policy

Description

The ChemiBrite™ FSH Glycoprotein Hormone Receptor Stable Cell Line measures FSHR (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

The ChemiBrite FSH Glycoprotein Hormone Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. follicle stimulating hormone) based activation of FSHR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses FSHR alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of FSHR , the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Calcium Flux
Cell Line 293H
For Use With (Application) Cell Lines
Primary Agonist FSH, Human
Quantity 2 Vials
Target Entry FSHR
Accession Number NM_000145
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