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CMPI hydrochloride, Tocris Bioscience™

Product Code. 30000762
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Quantity:
10 mg
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Description

Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs

Potent positive allosteric modulator of α4β2 nAChRs (EC50 values are 20 and 18 nM for rat and human, respectively). Selective for hα4β2 over hα3β2, hα3β4 and hα7. Inhibits (α4)2(β2)3, muscle-type and Torpedo nAChRs (IC50 values are 0.5, 0.7 and 0.2 μM, respectively), but not (α4)3(β2)2 receptors. Exhibits ability to photoincorporate into aliphatic and nucleophilic amino acid side chains.

Specifications

CAS 2250025-94-4
Linear Formula C18H19ClN4O.HCl
Quantity 10 mg
Synonym CMPI hydrochloride
Solubility Information Soluble to 50mM in water and to 100mM in DMSO
Formula Weight 379.28
Percent Purity >98%
Physical Form Solid
Chemical Name or Material 3-(2-Chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrazol-4-yl)isoxazole hydrochloride
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