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  6. Dexamethasone, 96%, Thermo Scientific Chemicals

Dexamethasone, 96%, Thermo Scientific Chemicals

Product Code. 10053130
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Quantity:
250 mg
1 g
5 g
Packaging:
Glass bottle

Description

Dexamethasone, CAS# 50-02-2, is a synthetic adrenal corticosteroid that shows potent anti-inflammatory activity.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Information

• Dexamethasone is a synthetic adrenal glucocorticoid that modulates carbohydrate metabolism, inhibits adrenocorticotropic hormone secretion, and has pronounced anti-inflammatory activity
• Dexamethasone can bind to specific nuclear steroid receptors, inhibiting pro-inflammatory signals, promoting anti-inflammatory signals, and interfering with NF-kB activation and apoptotic pathways

Applications

• It can be used to study apoptosis, cell signaling pathways, and gene expression
• This compound also shows adrenergic, antiemetic, and antineoplastic activities
• It has been used as an important regulator of cellular proliferation and differentiation in vitro human cell cultures
• Dexamethasone has been applied in culture media to promote the differentiation of adipose-derived stem cells into osteogenic tissue
• It is used in in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)
• This compound is used for its ability to regulate T cell survival, growth, and differentiation.
• It can also inhibit the induction of nitric oxide synthase.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 50-02-2
Molecular Formula C22H29FO5
Molecular Weight (g/mol) 392.47
MDL Number MFCD00064136
InChI Key UREBDLICKHMUKA-CXSFZGCWSA-N
Synonym dexamethasone, decadron, dexamethazone, maxidex, decaspray, desametasone, hexadecadrol, dexacort, dexasone, hexadrol
PubChem CID 5743
ChEBI CHEBI:41879
SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

Specifications

Melting Point 255.0°C to 261.0°C
Color White
Loss on Drying 0.5% max. (105°C, 3 hrs)
Infrared Spectrum Authentic
Assay Percent Range 96%
Packaging Glass bottle
Quantity 250 mg
Merck Index 15, 2945
Specific Rotation + 75.00
Solubility Information Solubility in water: 10mg/100mL (25 c). Other solubilities: soluble in acetone,ethanol and chloroform
Spectrophotometry 95% min. (on dried substance)
IUPAC Name (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Formula Weight 392.46
Percent Purity 96%
Related Substances (HPLC) Passes test
Physical Form Crystalline Powder
Chemical Name or Material Dexamethasone
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Safety and Handling

compliance-icons
Product Identifier
  • Dexamethasone
 Signal Word
  • Warning
 Hazard Category
  • Carcinogenicity Category 2
 Hazard Statement
  • H351-Suspected of causing cancer.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.

RUO – Research Use Only

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