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  7. Gabexate mesylate, Tocris Bioscience™

Gabexate mesylate, Tocris Bioscience™

Product Code. 18083932
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Quantity:
10 mg
50 mg
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Description

Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin

Gabexate mesylate is a serine protease inhibitor; Gabexate mesylate inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 μM respectively). Antithrombotic in vitro and in vivo. Gabexate mesylate also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation. Gabexate mesylate attenuates allergen-induced airway inflammation and eosinophils infiltration in the lung of asthma murine model.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 56974-61-9
Molecular Formula C17H27N3O7S
Molecular Weight (g/mol) 417.48
MDL Number MFCD00210299
InChI Key DNTNDFLIKUKKOC-UHFFFAOYSA-N
Synonym gabexate mesylate, gabexate mesilate, gabexate monomethanesulfonate, megacart, gabexate methanesulfonate, foy, dsstox_cid_25591, dsstox_rid_80986, dsstox_gsid_45591
PubChem CID 6604561
IUPAC Name ethyl 4-[(6-{[amino(azaniumyl)methylidene]amino}hexanoyl)oxy]benzoate methanesulfonate
SMILES CS([O-])(=O)=O.CCOC(=O)C1=CC=C(OC(=O)CCCCCN=C(N)[NH3+])C=C1

Specifications

Quantity 10 mg
Formula Weight 417.48
Percent Purity >98%
Chemical Name or Material Gabexate mesylate
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