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Thermo Scientific™ GeneBLAzer™ M1-NFAT-bla CHO-K1 Cells
GeneBLAzer™ M1-NFAT-bla CHO-K1 cells contain the human Acetylcholine (muscarinic) subtype 1 receptor (M1) stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line.
Brand: Thermo Scientific™ K1735
This item is not returnable.
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Description
GeneBLAzer™ M1-NFAT-bla CHO-K1 cells contain the human Acetylcholine (muscarinic) subtype 1 receptor (M1) stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line. CellSensor™ NFAT-bla CHO-K1 cells (Cat. No. K1534) contain a beta-lactamase (bla) reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.
M1-NFAT-bla CHO-K1 cells are functionally validated for Z'-factor and EC50 concentrations of carbachol. In addition, M1-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
In the brain, M1 activation mediates 'slow' neuronal excitability. Cortical and hippocampal muscarinic receptors are thought to be important in the attentional aspects of cognition. The predominant receptor subtypes in these brain areas are M1, M3, and M4. Therefore, M1 is a potential target for cognition, Alzheimer's, dementia, and schizophrenia. Studies on knock-out mouse models of M1 are also beginning to reveal potential functions of the receptor. Additional information on the muscarinic receptors can be found in reviews.
For Academic pricing please login or contact us at discoverysciences@invitrogen.com.
Specifications
| NM_000738 | |
| Dividing Cells | |
| Fluorescence | |
| M1 | |
| Single Cell Clone Origin | |
| 2 x 106 Cells | |
| M1 | |
| CHO-K1 | |
| GPCR |
| Cell-based beta lactamase reporter gene | |
| LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol. Includes: • GeneBLAzer™ M1-NFAT-bla CHO-K1 cells • GeneBLAzer™ M1-NFAT-bla CHO-K1 Assay Protocol • Certificate of Analysis The GeneBLAzer™ M1-NFAT-bla CHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt. |
|
| FRET | |
| M1-NFAT-bla CHO-K1 cells, M1-NFAT-bla CHO-K1 Assay Protocol, Certificate of Analysis | |
| GeneBLAzer™ | |
| BLA (Beta-Lactamase) | |
| Dividing Cells | |
| GeneBLAzer™ |
For Research Use Only. Not for use in diagnostic procedures.