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  8. GW 4064, Tocris Bioscience™

GW 4064, Tocris Bioscience™

Product Code. 18095942
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Selective farnesoid X receptor (FXR) agonist

GW 4064 is a potent and selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM). GW 4064 displays no activity at other nuclear receptors at concentrations up to 1 μM. Improves hyperglycaemia and hyperlipidemia in diabetic db/db mice. Shown to suppress autophagy in nutrient-deprived mouse hepatocytes. GW 4064 protects against lipopolysaccharide (LPS)-induced liver inflammation and apoptosis in mice. GW 4064 reduces Leptin signaling pathway activation in breast cancer cells and inhibits tumor growth in mouse xenografts.

Chemical Identifiers

CAS 278779-30-9
Molecular Formula C28H22Cl3NO4
Molecular Weight (g/mol) 542.837
InChI Key BYTNEISLBIENSA-MDZDMXLPSA-N
Synonym e-3-2-chloro-4-3-2,6-dichlorophenyl-5-isopropylisoxazol-4-yl methoxy styryl benzoic acid, unii-sr225wuz0h, sr225wuz0h, 3-2-2-chloro-4-3-2,6-dichlorophenyl-5-isopropylisoxazol-4-ylmethoxy phenyl vinyl benzoic acid, benzoic acid, 3-2-2-chloro-4-3-2,6-dichlorophenyl-5-1-methylethyl-4-isoxazolyl methoxy phenyl ethenyl, 3-2,6-dichlorophenyl-4-3'-carboxy-2-chlorostilben-4-yl oxymethyl-5-isopropylisoxazole, 3-e-2-2-chloro-4-3-2,6-dichlorophenyl-5-1-methylethyl isoxazol-4-yl methoxy phenyl ethenyl benzoic acid, 3-e-2-2-chloro-4-3-2,6-dichlorophenyl-5-propan-2-yl-1,2-oxazol-4-yl methoxy phenyl ethenyl benzoic acid, 3-2-2-chloro-4-3-2,6-dichlorophenyl-5-1-methylethyl-4-isoxazolyl methoxy phenyl ethenyl benzoic acid
PubChem CID 9893571
ChEBI CHEBI:79997
IUPAC Name 3-[(E)-2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]methoxy]phenyl]ethenyl]benzoic acid
SMILES CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)C=CC4=CC(=CC=C4)C(=O)O)Cl

Specifications

Quantity 10 mg
Formula Weight 542.84
Percent Purity >97%
Chemical Name or Material GW 4064
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