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Gibco™ Human OATP1A2 (G) SLC Transporter Cells
HEK293 cells that transiently overexpress the OATP2B1 solute carrier (SLC) transport protein
Brand: Gibco™ GM1116G
This item is not returnable.
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Description
- TRANSiPORT Human OATP1A2 (G) SLC Transporter Cells are HEK293 cells that transiently overexpress the OATP2B1 solute carrier (SLC) transport protein. Solute carriers are a super-family of membrane transporters that can affect pharmacokinetics and drug exposure by governing the transport of solutes in and out of cells. The OATP1A2 SLC transporter protein is found in hepatocytes.
- Assess potential for transporter-mediated drug metabolism
- Easy-to-use format
- Obtain high-quality results with a large signal-to-noise ratio
- Cell-based assays can be performed using radioisotope-labeled compounds, fluorescence-labeled compounds, or non-labeled compounds. The amount of substrate transported into the cells can be measured directly using a liquid scintillation counter, fluorescence plate reader, or LC-MS/MS, thereby allowing direct evaluation of SLC transporter activity.
- Mock OATP1A2 (G) SLC Transporter Cells (Cat. No. GM1017) that do not overexpress the OATP1A2 SLC transporter are available for use as a negative experimental control. Some compounds may demonstrate high background levels of transport due to the presence of endogenous transporters or non-specific binding.
- The convenient product format enables data generation in two days from thawing of the cells to final results.
Specifications
| Store in liquid nitrogen vapor phase. | |
| Mammalian Cell Culture | |
| 8-10 x 106 cells |
| 293 (HEK) | |
| Human | |
| SLC Transporter Cell |