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  8. JNJ 10397049, Tocris Bioscience™

JNJ 10397049, Tocris Bioscience™

Product Code. 30001467
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Quantity:
10 mg
50 mg
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Description

Selective OX2 receptor antagonist

Selective OX2 receptor antagonist (pIC50 = 7.4 for chimeric OX2 receptors; pKB values are 5.9 and 8.5 for OX1 and OX2 receptors respectively). Shows no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. Achieves high level of OX2 receptor occupancy in the rat brain; exhibits sleep-promoting effects in rats.

Chemical Identifiers

CAS 708275-58-5
Molecular Formula C19H20Br2N2O3
Molecular Weight (g/mol) 484.188
InChI Key RBKIJGLHFFQHBE-IRXDYDNUSA-N
Synonym unii-1b419p24av, n-2,4-dibromophenyl-n'-4s,5s-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl-urea, 1-2,4-dibromophenyl-3-4s,5s-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl urea, d01sul, compound 9 pmid: 15261275, 1-2,4-dibromophenyl-3-4s,5s-2,2-dimethyl-4-phenyl-1,3 dioxan-5-yl urea, urea, n-2,4-dibromophenyl-n'-4s,5s-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl, 3-2,4-dibromophenyl-1-4s,5s-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl urea
PubChem CID 9869934
IUPAC Name 1-(2,4-dibromophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea
SMILES CC1(OCC(C(O1)C2=CC=CC=C2)NC(=O)NC3=C(C=C(C=C3)Br)Br)C

Specifications

Quantity 10 mg
Formula Weight 484.18
Percent Purity >99%
Chemical Name or Material JNJ 10397049
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