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  7. JNJ 28871063 hydrochloride, Tocris Bioscience™

JNJ 28871063 hydrochloride, Tocris Bioscience™

Product Code. 18055512
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent ErbB receptor family inhibitor

Potent and selective ErbB receptor family inhibitor (IC50 values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro (IC50 = 60 - 168 nM) and inhibits growth of human tumor xenografts in vivo. Brain penetrant and orally active.

Chemical Identifiers

CAS 944342-90-9
Molecular Formula C24H28Cl2N6O3
Molecular Weight (g/mol) 519.427
InChI Key ZXKZRKQMKNRZNN-GZPZNDDGSA-N
Synonym 5e-4-amino-6-4-benzyloxy-3-chlorophenylamino pyrimidine-5-carboxaldehyde n-2-morpholin-4-ylethyl oxime hydrochloride
PubChem CID 17747413
IUPAC Name 4-N-(3-chloro-4-phenylmethoxyphenyl)-5-[(E)-2-morpholin-4-ylethoxyiminomethyl]pyrimidine-4,6-diamine;hydrochloride
SMILES C1COCCN1CCON=CC2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N.Cl

Specifications

Quantity 10 mg
Formula Weight 519.42
Percent Purity >97%
Chemical Name or Material JNJ 28871063 hydrochloride
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