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Ki-67 Monoclonal Antibody (20Raj1), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
1544.00 € - 3585.00 €
Specifications
Antigen | Ki-67 |
---|---|
Clone | 20Raj1 |
Concentration | 0.5 mg/mL |
Classification | Monoclonal |
Conjugate | Unconjugated |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17160672
|
Invitrogen
14-5699-37 |
2 mg |
1544.00 €
2mg |
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17170672
|
Affymetrix eBioscience
14-5699-95 |
10 mg | N/A | ||||||
Description
The MAb 20Raj1 recognizes the human Ki-67 protein. Two isoforms of Ki-67 exist, a 345 and 395 kDa form that are expressed in dividing cells. Ki-67 is expressed in all cell types and is detectable during active phases of the cell cycle (G1, S, G2, and mitosis) but is absent from resting cells (G0). During interphase, Ki-67 expression is localized to the nucleus but redistributes to the chromosomes during mitosis and has specifically been found to associate with heterochromatin-bound proteins such as chromobox protein homolog 3 (CBX3). In studies of tumor cells, Ki-67 expression has been used as a marker for determining the fraction of proliferating cells within a given population of tumor cells. This MAb 20Raj1 recognizes canine (dog) Ki-67.
Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki-67 index and histologically low-grade tumors is strong. Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation.Specifications
Ki-67 | |
0.5 mg/mL | |
Unconjugated | |
Mouse | |
Canine, Human | |
P46013 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
20Raj1 | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.09% sodium azide; pH 7.2 | |
100686578, 4288 | |
Primary | |
4° C | |
Mki67 |
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