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Minocycline hydrochloride, Tocris Bioscience™

Product Code. 18064532
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Antibiotic. Displays neuroprotective effects

Minocycline hydrochloride is a tetracycline antibiotic. Displays neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Orally active and brain penetrant. Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), (S)-(+)-Dimethindene maleate (Cat.No. 1425) and human leukemia inhibitory factor.

For more information about how Minocycline hydrochloride may be used, see our protocol: Generation and Propagation of EPS cells (LCDM Cocktail) .

Specifications

CAS 13614-98-7
Molecular Formula C23H28ClN3O7
MDL Number MFCD00083669
Quantity 50 mg
Synonym minocycline hydrochloride, minocycline hcl, minomycin, minocin, minocycline chloride, arestin, vectrin, minomax, periocline, tri-mino
InChI Key KDLQIOPKJDNQIM-WUURTAMISA-N
SMILES [H+].[Cl-].CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(O)=C4C(O)=C3C(=O)[C@]2(O)C(=O)\C(=C(\N)O)C1=O)N(C)C
IUPAC Name hydrogen (2Z,4S,4aS,5aR,12aS)-2-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-1,2,3,4,4a,5,5a,6,12,12a-decahydrotetracene-1,3,12-trione chloride
Molecular Weight (g/mol) 493.94
PubChem CID 54685925
Formula Weight 493.94
Percent Purity >98%
Chemical Name or Material Minocycline hydrochloride
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