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MKNK2 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA513809
This item is not returnable.
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Description
This antibody is predicted to react with mouse and rat based on sequence homology.
The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases, regulate protein synthesis by phosphroylation eIF4E on Ser209, and may contribute to tumorigenesis. Overexpression of Mnk2 results in increased phosphorylation of endogenous eIF-4E, showing that it can act as an eIF-4E kinase in vivo. Mnk2 may play a role in the response to environmental stress and cytokines. Expression of active mutants of MNK1 and MNK2 in 293 cells diminishes cap-dependent translation relative to cap-independent translation in a transient reporter assay. Human Mnk2 is homologous to murine Mnk2 (approximately 94% identical) and human Mnk1 (71% identical). In vitro phosphorylation studies show that Mnk2 is a significantly better substrate than Mnk1 for extracellular signal-regulated kinase 2 (Erk2), p38MAPKalpha, and p38MAPKbeta.
Specifications
| MKNK2 | |
| Polyclonal | |
| Unconjugated | |
| Mknk2 | |
| 2010016G11Rik; G protein-coupled receptor kinase 7; GPRK7; MAP kinase interacting serine/threonine kinase 2; MAP kinase signal-integrating kinase 2; MAP kinase-interacting serine/threonine kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 2; MAPK interacting serine/threonine kinase 2; MAPK signal-integrating kinase 2; Mknk2; MNK2 | |
| Rabbit | |
| Ammonium sulfate precipitation, Size-exclusion - Dialysis | |
| RUO | |
| 17347, 2872 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Western Blot | |
| 2 mg/mL | |
| PBS with 0.09% sodium azide | |
| Q8CDB0, Q9HBH9 | |
| Mknk2 | |
| KLH conjugated synthetic peptide between 70-100 amino acids from the N-terminal region of human MNK2 (MKNK2) | |
| 400 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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