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PD 158780, Tocris Bioscience™

Product Code. 18054962
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent ErbB receptor family inhibitor

Potent inhibitor of ErbB receptor family tyrosine kinases (IC50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 171179-06-9
Molecular Formula C14H12BrN5
Molecular Weight (g/mol) 330.19
MDL Number MFCD00942160
InChI Key KFHMLBXBRCITHF-UHFFFAOYSA-N
Synonym n4-3-bromophenyl-n6-methylpyrido 3,4-d pyrimidine-4,6-diamine, chembl53753, insolution pd 158780, 4-n-3-bromophenyl-6-n-methylpyrido 3,4-d pyrimidine-4,6-diamine, 4-3-bromoanilino-6-methylaminopyrido 3,4-d pyrimidine, 4-3-bromophenyl amino-6-methylamino pyrido 3,4-d pyrimidine, 4-3-bromophenyl amino-6-methylamino-pyrido 3,4-d pyridimine, n4-3-bromophenyl-n6-methyl-pyrido 3,4-d pyrimidine-4,6-diamine, pyrido 3,4-d pyrimidine-4,6-diamine, n4-3-bromophenyl-n6-methyl
PubChem CID 4707
IUPAC Name N4-(3-bromophenyl)-N6-methylpyrido[3,4-d]pyrimidine-4,6-diamine
SMILES CNC1=NC=C2N=CN=C(NC3=CC(Br)=CC=C3)C2=C1

Specifications

Quantity 50 mg
Formula Weight 330.18
Percent Purity >99%
Chemical Name or Material PD 158780
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