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Phospho-SF3B1 (Thr313) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA5104648
This item is not returnable.
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Description
Antibody detects endogenous levels of SF3B1 only when phosphorylated at Thr313.
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex. The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.
Specifications
| Phospho-SF3B1 (Thr313) | |
| Polyclonal | |
| Unconjugated | |
| SF3B1 | |
| 155kDa; 2810001M05Rik; AA409119; Hsh155; LOW QUALITY PROTEIN: splicing factor 3B subunit 1; MDS; pre-mRNA processing 10; pre-mRNA splicing factor SF3b, 155 kDa subunit; pre-mRNA-splicing factor SF3b 155 kDa subunit; PRP10; PRPF10; SAP 155; SAP155; SF3B1; SF3b155; spliceosome-associated protein 155; Splicing factor 3B subunit 1; splicing factor 3b subunit 1, 155kDa; splicing factor 3b, subunit 1; splicing factor 3b, subunit 1, 155 kDa; splicing factor 3b, subunit 1, 155kD; splicing factor 3b, subunit 1, 155kDa; TA-8; Targ4; transforming growth factor alpha regulated gene 4; tst; wu:fb99f09 | |
| Rabbit | |
| sequential chromatography | |
| RUO | |
| 23451, 81898, 84486 | |
| -20°C | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| O75533, Q99NB9 | |
| SF3B1 | |
| A synthesized peptide derived from human SF3B1(Accession O75533), corresponding to amino acid residues around phosphorylated Thr313. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |