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Propargyl bromide, 80% in toluene, stab. with MgO, Thermo Scientific Chemicals
Description
Propargyl bromide, 80% in toluene is used to prepare betulonic acid-peptide conjugates with anti-inflammatory activity and propargylic amines employed in enyne metathesis. It finds application in the propargylation of spiro ketones, allylic alcohols and enone complexes. In Barbier-type reaction, it reacts with aldehydes to give alkyne alcohols. It is actively involved in the synthesis of polyethylene glycol (PEG) and peptide-grafted polyesters.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Propargyl bromide, 80% in toluene is used to prepare betulonic acid-peptide conjugates with anti-inflammatory activity and propargylic amines employed in enyne metathesis. It finds application in the propargylation of spiro ketones, allylic alcohols and enone complexes. In Barbier-type reaction, it reacts with aldehydes to give alkyne alcohols. It is actively involved in the synthesis of polyethylene glycol (PEG) and peptide-grafted polyesters.
Solubility
Miscible with ethanol, ether, benzene, carbon tetrachloride and chloroform. Immiscible with water.
Notes
Light sensitive. Store in a cool place. Incompatible withbases, strong oxidizing agents, copper, peroxides, silver, silver oxides, mercury and mercury oxides.
Specifications
Specifications
| Melting Point | -61°C |
| Density | 1.335 |
| Boiling Point | 88°C to 90°C |
| Flash Point | 3°C (37°F) |
| Refractive Index | 1.494 |
| Quantity | 50 mL |
| UN Number | UN2924 |
| Beilstein | 605309 |
| Sensitivity | Light sensitive |
| Solubility Information | Miscible with ethanol,ether,benzene,carbon tetrachloride and chloroform. Immiscible with water. |
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Safety and Handling
- Propargyl bromide, 80% in toluene
- Danger
- Acute toxicity Category 3
- Aspiration toxicity Category 1
- Serious eye damage/eye irritation Category 1
- Flammable liquid Category 2
- Reproductive toxicity Category 2
- Skin corrosion/irritation Category 1 B
- Specific target organ toxicity after repeated exposure Category 2
- Specific target organ toxicity Category 3
- H225-Highly flammable liquid and vapour.
- H304-May be fatal if swallowed and enters airways.
- H314-Causes severe skin burns and eye damage.
- H318-Causes serious eye damage.
- H331-Toxic if inhaled.
- H336-May cause drowsiness or dizziness.
- H361-Suspected of damaging fertility or the unborn child.
- H373-May cause damage to organs.
- P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- P260-Do not breathe dust/fume/gas/mist/vapours/spray.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P331-Do NOT induce vomiting.
- MIXTURE LIST-Contains : Propargyl bromide, Toluene
RUO – Research Use Only
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