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Tocris Bioscience™ Selinexor
Selective exportin 1 (XPO1/CRM1) inhibitor
211.00 € - 825.00 €
Specifications
| Chemical Name or Material | (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide |
|---|---|
| CAS | 1393477-72-9 |
| Target | Antiviral Compounds |
| Molecular Formula | C17H11F6N7O |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18737176
|
Tocris Bioscience™
7760/10 |
10 mg |
211.00 €
10mg |
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|
18736116
|
Tocris Bioscience™
7760/50 |
50 mg |
825.00 €
50mg |
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Descripción
Selinexor is an inhibitor of the exportin 1 (XPO1/CRM1) nuclear exporter. Shows selectivity for TNBC over ER-positive breast cancer cell lines (IC50 values are 11-550 nM and >1000 nM, respectively), and reduces growth of xenografts. Inhibits growth of thyroid cancer cell lines (IC50 = 150-500 nM), potentiates the anti-tumor effects of Olaparib (Cat. No. 7579) in ovarian cancer and breast cancer. Also a potent inhibitor of SARS-CoV-2 replication in vitro (EC50 = 10 nM) and downregulates the production of pro-inflammatory cytokines including TNF-α and IL-6.Especificaciones
| (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide | |
| 1393477-72-9 | |
| Antiviral Compounds | |
| C17H11F6N7O |
Seguridad y manipulación
Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.