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T 0901317, Tocris Bioscience™

Product Code. 18094502
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Quantity:
10 mg
50 mg
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Description

Potent liver X receptor (LXR) agonist; also CAR inverse agonist

Potent, high affinity liver X receptor (LXR) agonist (EC50 ∽ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC50 of ∽ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).

Chemical Identifiers

CAS 293754-55-9
Molecular Formula C17H12F9NO3S
Molecular Weight (g/mol) 481.333
InChI Key SGIWFELWJPNFDH-UHFFFAOYSA-N
Synonym n-4-1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl phenyl-n-2,2,2-trifluoroethyl benzenesulfonamide, chembl62136, n-2,2,2-trifluoroethyl-n-4-2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl ethyl phenyl benzenesulfonamide, n-2,2,2-trifluoroethyl-n-4-2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl phenyl sulfonamide, 1pqc, d0b5fc, n-4-1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2-yl phenyl-n-2,2,2-trifluoroethyl benzenesulfonamide, t, benzenesulfonamide, n-2,2,2-trifluoroethyl-n-4-2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl ethyl phenyl
PubChem CID 447912
ChEBI CHEBI:39976
IUPAC Name N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
SMILES C1=CC=C(C=C1)S(=O)(=O)N(CC(F)(F)F)C2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O

Specifications

Quantity 10 mg
Formula Weight 481.33
Percent Purity >98%
Chemical Name or Material T 0901317
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