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Triptolide, Tocris Bioscience™

Product Code. 18045412
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Quantity:
1 mg
10 mg
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This item is not returnable. View return policy

Description

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

Triptolide inhibits DNA-dependent ATPase activity of XBP and induces inhibition of RNA polymerase II (RNAPII)-mediated transcription (IC50 = 200 nM). Selective for RNAPII over RNAPI and RNAPIII. Triptolide blocks RNA synthesis in HeLa cells (IC50 = 62 nM); exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and induces apoptosis by blocking TNF-α-mediated c-IAP1 and c-IAP2 induction. Also displays immunosuppressive and anti-inflammatory activity.

Chemical Identifiers

CAS 38748-32-2
Molecular Formula C20H24O6
Molecular Weight (g/mol) 360.41
MDL Number MFCD00210565
InChI Key DFBIRQPKNDILPW-CIVMWXNOSA-N
Synonym triptolide, triptolid, unii-19ald1s53j, triptolide, tripterygium wilfordii, --triptolide, trisoxireno 4b,5:6,7:8a,9 phenanthro 1,2-c furan-1 3h-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-1-methylethyl-, 3bs,4as,5as,6r,6ar,7as,7bs,8as,8bs, triptolide, 1, triptolide pg490 /, d0i6lh, 3bs,4as,5as,6r,6ar,7as,7bs,8as,8bs-6-hydroxy-6a-isopropyl-8b-methyl-3b,4,4a,6,6a,7a,7b,8b,9,10-decahydrotrisoxireno 6,7:8a,9:4b,5 phenanthro 1,2-c furan-1 3h-one
PubChem CID 107985
ChEBI CHEBI:9747
IUPAC Name (1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-(propan-2-yl)-3,6,10,16-tetraoxaheptacyclo[11.7.0.0²,⁴.0²,⁹.0⁵,⁷.0⁹,¹¹.0¹⁴,¹⁸]icos-14(18)-en-17-one
SMILES [H][C@@]12C[C@@H]3O[C@@]33[C@H](O)[C@]4(O[C@H]4[C@@H]4O[C@]34[C@@]1(C)CCC1=C2COC1=O)C(C)C

Specifications

Quantity 1 mg
Formula Weight 360.4
Percent Purity >98%
Chemical Name or Material Triptolide
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