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XAV 939, Tocris Bioscience™

Product Code. 18065872
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent tankyrase inhibitor

XAV 939 is a potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the β-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyocyte differentiation in mesoderm progenitor cells. Also used in neuronal differentiation protocols.

XAV 939 synthesized to cGMP guidelines also available.

For more information about how XAV 939 may be used, see our protocol: Accelerated Induction of Cortical Neurons from hiPSCs

Chemical Identifiers

CAS 284028-89-3
Molecular Formula C14H11F3N2OS
Molecular Weight (g/mol) 312.31
InChI Key KLGQSVMIPOVQAX-UHFFFAOYSA-N
Synonym 3,5,7,8-tetrahydro-2-4-trifluoromethyl phenyl-4h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-7,8-dihydro-5h-thiopyrano 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-7,8-dihydro-5h-thiino 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-ol, 2-4-trifluoromethyl phenyl-1,5,7,8-tetrahydrothiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-1,5,7,8-tetrahydro-4h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-1h,5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-one, 2-4-trifluoromethyl phenyl-3h,5h,7h,8h-thiopyrano 4,3-d pyrimidin-4-one
PubChem CID 2726824
ChEBI CHEBI:62878
IUPAC Name 2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
SMILES C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F

Specifications

Quantity 10 mg
Formula Weight 312.31
Percent Purity >98%
Chemical Name or Material XAV 939
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