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Amlexanox, Tocris Bioscience™

Product Code. 30001599
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Selective inhibitor of TBK

Selective inhibitor of TANK-binding kinase 1 (TBK1) and IKKε (IC50 values are ∽1-2 μM). Displays no effect on IKKα or IKKβ at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro.

Chemical Identifiers

CAS 68302-57-8
Molecular Formula C16H14N2O4
Molecular Weight (g/mol) 298.30
MDL Number MFCD00864790
InChI Key SGRYPYWGNKJSDL-UHFFFAOYSA-N
Synonym amlexanox, aphthasol, amoxanox, 2-amino-7-isopropyl-5-oxo-5h-chromeno 2,3-b pyridine-3-carboxylic acid, amlenanox, solfa, amlexanoxo, amlexanoxum, amlexanoxum latin, amlexanoxo spanish
PubChem CID 2161
ChEBI CHEBI:31205
IUPAC Name 2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
SMILES CC(C)C1=CC=C2OC3=NC(N)=C(C=C3C(=O)C2=C1)C(O)=O

Specifications

Quantity 10 mg
Formula Weight 298.29
Percent Purity >99%
Chemical Name or Material Amlexanox
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