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Tocris Bioscience™ AZD 7648
Potent and selective DNA-PK inhibitor
210.00 € - 810.00 €
Specifications
| Chemical Name or Material | 7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one |
|---|---|
| CAS | 2230820-11-6 |
| Target | DNA-dependent Protein Kinase Inhibitors |
| Molecular Formula | C18H20N8O2 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18779796
|
Tocris Bioscience™
7825/10 |
10 mg |
210.00 €
10mg |
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|
18799076
|
Tocris Bioscience™
7825/50 |
50 mg |
810.00 €
50mg |
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Description
AZD 7648 is a potent (IC50 = 0.6 nM in an enzyme assay) and selective DNA-PK inhibitor. It is selective for DNA-PK over a range of kinases including PI3Kα, PI3Kδ, PI3Kγ, ATM, ATR and mTOR. In combination with radiotherapy, it leads to tumor regression in fully immuno-competent mice models. It also enhances the activity of PARP inhibitor Olaparib (Cat. No. 7579). AZD 7648 is orally bioavailable.Specifications
| 7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one | |
| 2230820-11-6 | |
| DNA-dependent Protein Kinase Inhibitors | |
| C18H20N8O2 |
Safety and Handling
Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.