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Chorionic Gonadotropin Monoclonal Antibody (FB12), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 14-6508-95
This item is not returnable.
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Description
This FB12 MAb reacts with human Chorionic Gonadotropin (hCG). This secreted glycoprotein is composed of an alpha subunit, which is common to other peptide hormones such as luteinizing hormone (LH), follicle stimulating hormone (FSH) and thyroid stimulating hormone (TSH), and a beta subunit which determines the specificity of the hormone. FB12 recognizes both the intact hCG (composed of the alpha and beta subunits) as well as the free beta subunit, highly expressed in both choriocarcinoma and the serum of pregnant women. hCG is normally expressed by trophoblastoid cells (syncytiotrophoblasts and extravillous cytotrophoblasts) that are responsible for maintenance of the corpus luteum during early gestation. hCG plays an important role in the regulation of angiogenesis through activation of the PI3K/mTOR pathway, resulting in upregulation of vascular endothelial growth factor (VEGF). Ectoptic expression of hCG has also been reported in multiple types of cancer (bladder, lung, breast, pancreas, renal).
Chorionic Gonadotropin Monoclonal antibody specifically detects Chorionic Gonadotropin in Human samples. It is validated for ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
Specifications
| Chorionic Gonadotropin | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| P01215, P0DN86 | |
| Mouse | |
| 10 mg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 κ |
| ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot | |
| FB12 | |
| Unconjugated | |
| CGB3 | |
| anterior pituitary glycoprotein hormones common subunit alpha; CGA; CG-alpha; CGB; CGB3; CGB5; CGB7; CGB8; CG-beta; choriogonadotropin alpha chain; Choriogonadotropin subunit beta; choriogonadotropin subunit beta 3; chorionic gonadotrophin chain beta; Chorionic gonadotrophin subunit alpha; chorionic gonadotropin beta 3 subunit; chorionic gonadotropin beta 5 subunit; chorionic gonadotropin beta 8 subunit; chorionic gonadotropin beta chain; chorionic gonadotropin beta subunit; chorionic gonadotropin beta subunit 3; chorionic gonadotropin beta subunit 5; chorionic gonadotropin beta subunit 8; chorionic gonadotropin chain beta; chorionic gonadotropin human; chorionic gonadotropin, alpha polypeptide; chorionic gonadotropin, beta polypeptide; chorionic gonadotropin, beta polypeptide 5; chorionic gonadotropin, beta polypeptide 8; follicle-stimulating hormone alpha chain; follicle-stimulating hormone alpha subunit; follitropin alpha chain; FSHA; FSH-alpha; Glycoprotein hormones alpha chain; gl | |
| Affinity chromatography | |
| RUO | |
| 1081, 1082, 93659, 94115 | |
| 4° C | |
| Liquid |
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Product Title
Chorionic Gonadotropin Monoclonal Antibody (FB12), eBioscience™, Invitrogen™ > 10 mg; Unconjugated
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