missing translation for 'onlineSavingsMsg'
Learn More

Chorionic Gonadotropin Monoclonal Antibody (FB12), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

1544.00 € - 3585.00 €

Specifications

Antigen Chorionic Gonadotropin
Clone FB12
Concentration 0.5 mg/mL
Classification Monoclonal
Conjugate Unconjugated
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17168535
View Documents
Invitrogen
14-6508-37
2 mg
1544.00 €
2mg
Please to purchase this item. Need a web account? Register with us today!
17178535
View Documents
Affymetrix eBioscience
14-6508-95
10 mg This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
N/A
Description

Description

This FB12 MAb reacts with human Chorionic Gonadotropin (hCG). This secreted glycoprotein is composed of an alpha subunit, which is common to other peptide hormones such as luteinizing hormone (LH), follicle stimulating hormone (FSH) and thyroid stimulating hormone (TSH), and a beta subunit which determines the specificity of the hormone. FB12 recognizes both the intact hCG (composed of the alpha and beta subunits) as well as the free beta subunit, highly expressed in both choriocarcinoma and the serum of pregnant women. hCG is normally expressed by trophoblastoid cells (syncytiotrophoblasts and extravillous cytotrophoblasts) that are responsible for maintenance of the corpus luteum during early gestation. hCG plays an important role in the regulation of angiogenesis through activation of the PI3K/mTOR pathway, resulting in upregulation of vascular endothelial growth factor (VEGF). Ectoptic expression of hCG has also been reported in multiple types of cancer (bladder, lung, breast, pancreas, renal).

Human chorionic gonadotropin (hCG) is a placental hormone that stimulates secretion of the pregnancy-sustaining steroid progesterone. hCG is a member of a family of glycoprotein hormones including pituitary hormones lutropin (luteinizing hormone;LH), follitropin (follicle-stimulating hormone; FSH) and thyrotropin (thyroid-stimulating hormone; TSH). Members of this family are all composed of disulfide-rich heterodimers with two dissimilar subunits namely alpha- and beta-subunits. The alpha subunit is common to all the members of the family within a given species. The beta subunits are distinct in each of the horomones and confer the receptor and biological specificity.
Specifications

Specifications

Chorionic Gonadotropin
0.5 mg/mL
Unconjugated
Mouse
Human
P01215, P0DN86
IgG1 κ
Affinity chromatography
Antibody
FB12
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
1081, 1082, 93659, 94115
Primary
4° C
Videos
SDS
Documents

Documents

Product Certifications
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title
Chorionic Gonadotropin Monoclonal Antibody (FB12), eBioscience™, Invitrogen™

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.