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Tocris Bioscience™ DL-AP5 Sodium salt

Potent and selective NMDA antagonist; sodium salt of DL-AP5

Brand:  Tocris Bioscience™ 3693/10

98.27 EUR valid until 2024-12-16
Use promo code "21630" to get your promotional price.


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Product Code. 18044332

  • 126.00 € / 10mg

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Description

Description

DL-AP5 Sodium salt is the sodium salt of DL-AP5 (Cat. No. 0105) and a racemic mixture of the D- and L-isomers of AP5, a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 (Cat. No. 0106) is the more active isomer and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection of D-AP5, NMDA-response is rapidly reduced, with no effect seen on spontaneously active neurons.

DL mixture, D-isomer and L-isomer also available.

Specifications

Specifications

>98%
DL-AP5 Sodium salt
DL-AP5 Sodium salt
10 mg
219.11
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