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Etoposide, Thermo Scientific™ Product Code.: 15405829
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Etoposide, Thermo Scientific™

Product Code. 15405829
100mg
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Quantity:
25mg
100mg
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Product Code. 15405829

Brand: Thermo Scientific Alfa Aesar J63651.MC

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Description

Topoisomerase inhibitor and inducer of apoptosis

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

Solubility
Insoluble in water.

Notes
Store solutions in DMSO at 4°C. For long term storage prepare aliquots and store at -20°C.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 33419-42-0
Molecular Formula C29H32O13
Molecular Weight (g/mol) 588.56
MDL Number MFCD00869325,MFCD00869325
InChI Key VJJPUSNTGOMMGY-MRVIYFEKSA-N
Synonym vjjpusntgommgy-nzlmilqcsa
PubChem CID 50936917
IUPAC Name (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-oneShow MoreShow Less
SMILES COC1=CC(=CC(OC)=C1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)C2=CC3=C(OCO3)C=C12Show MoreShow Less

Specifications

Quantity 100mg
Merck Index 14,3886
Solubility Information Insoluble in water.
Optical Rotation −107° (c=1 in Methanol/Dichloromethane 1:9)
Formula Weight 588.56
Chemical Name or Material Etoposide

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Lot Number Certificate Type Date Catalog Number
Lot NumberQ02L021 Certificate TypeCertificate of Analysis Date03/04/2025 Catalog NumberJ63651.MB,J63651.MC
Lot NumberQ02L020 Certificate TypeCertificate of Analysis Date03/04/2025 Catalog NumberJ63651.MB,J63651.MC
Lot NumberN11L021 Certificate TypeCertificate of Analysis Date13/02/2025 Catalog NumberJ63651.MB,J63651.MC
Lot NumberM31L027 Certificate TypeCertificate of Analysis Date03/02/2025 Catalog NumberJ63651.MB,J63651.MC
Lot NumberY13K046 Certificate TypeCertificate of Analysis Date19/11/2024 Catalog NumberJ63651.MB,J63651.MC

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