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Thermo Scientific™ CellSensor™ SBE-bla A375 Cell Line

Bone morphogenetic proteins (BMPs), members of the transforming growth factor beta (TGF-β) superfamily, play important roles in the development of the heart, central nervous system and cartilage.

Brand:  Thermo Scientific™ K1514

Product Code. 10685875

  • 11800.00 € / Each
Estimated Shipment: 02-04-2025
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Description

Description

Bone morphogenetic proteins (BMPs), members of the transforming growth factor beta (TGF-β) superfamily, play important roles in the development of the heart, central nervous system and cartilage. Disruption of BMP signaling affects the body plan of the developing embryo. BMPs propagate their signal by activating Activin receptor-like kinase (ALK), which in turn mediates the phosphorylation of R-Smads. Phosphorylated R-Smad associates with Smad4 and then translocates to the nucleus regulating gene expression. A375 cells are human malignant melanoma cells containing endogenous Smad signaling pathway. SBE-bla A375 cell line was engineered to express beta-lactamase under the control of Smad binding element. This cell line has been validated for Z' and EC50 under optimized conditions using BMP-4. This cell line has also responded to Nodal and was tested for assay performance under variable conditions, including DMSO concentration, cell number, stimulation time, substrate loading time. Additional information using various small molecule inhibitors and StealthTM RNAi is also provided.

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Specifications

Specifications

Cell-based beta lactamase reporter gene
CellSensor™ SBE-bla A375 cells are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use.
Fluorescence
CellSensor™
ALK5, ALK7, TGF beta/BMP pathway
A375
Signaling Pathway
Dividing Cells
Cell Line: A375
Signaling Pathway
1 Vial
Dividing Cells
CellSensor™
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Lot Number Certificate Type Date Catalog Number
Lot Number40731 Certificate TypeCertificate of Analysis Date15/04/2017 Catalog NumberK1514
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