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Thermo Scientific™ SPDP (succinimidyl 3-(2-pyridyldithio)propionate)

Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups on 3-atom spacer arm; forms cleavable disulfide bonds with cysteines.

Brand: Thermo Scientific™ 21857

204.25 EUR valid until 2025-05-31
Use promo code "25977" to get your promotional price.

Product Code. 10220264

221.00 € / 50mg

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This item is not returnable. View return policy

Description

Thermo Scientific™ Pierce SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

Highlights:

Widely used in immunochemistry; conjugates used in drug carrier systems, antibody production and enzyme immunoassays
Can be used as a protein thiolation reagent
Reactive groups: NHS ester and pyridyldisulfide
Reactive toward: amino and sulfhydryl groups

Specifications

Chemical Reactivity	Amine-Sulfhydryl
Description	SPDP
PEGylated	No
Content And Storage	Upon receipt store at -20°C protected from moisture.
Shipping Condition	Ambient
Labeling Method	Chemical Labeling
Reactive Moiety	NHS Ester, Pyridyldisulfide
Form	Powder
Solubility	DMF, DMSO
Water Soluble	No

Cleavable	By Thiols
Molecular Weight (g/mol)	312.36
Spacer Arm Length	6.8 Å
Cell Permeability	Yes
Product Line	Pierce™
Crosslinker Type	Heterobifunctional
Spacer	Short (<10 Å)
Quantity	50 mg
Format	Standard, Premium-grade
Product Type	Crosslinker

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Safety and Handling

Product Identifier

SPDP (succinimidyl 3-(2-pyridyldithio)propionate)

Signal Word

Warning

Hazard Category

Serious eye damage/eye irritation Category 2
Skin corrosion/irritation Category 2
Specific target organ toxicity Category 3

Hazard Statement

H315-Causes skin irritation.
H319-Causes serious eye irritation.
H335-May cause respiratory irritation.

Precautionary Statement

P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
P264-Wash hands thoroughly after handling.
P271-Use only outdoors or in a well-ventilated area.
P280-Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352-IF ON SKIN: Wash with plenty of water/soap.
P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312-Call a POISON CENTER/doctor/if you feel unwell.
P332+P313-If skin irritation occurs: Get medical advice/attention.
P337+P313-If eye irritation persists: Get medical advice/attention.
P362+P364-Take off contaminated clothing and wash it before reuse.
P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

MIXTURE LIST-Contains : 1-[1-Oxo-3-(2-pyridyldithio)pro poxy]pyrrolidine-2,5-dione

Documents

Product Information

Manuals

User Guide: SPDP Crosslinkers Version: Jan. 2015 File size: 110.2 kB

Certificates

A lot number is required to show results for certificates. To find your lot number on previous orders use our order status area.

Lot Number

5 results found

Lot Number	Certificate Type	Date	Catalog Number
Lot NumberZI402962	Certificate TypeCertificate of Analysis	Date16/12/2024	Catalog Number21857
Lot NumberZI401347	Certificate TypeCertificate of Analysis	Date15/10/2024	Catalog Number21857
Lot NumberZG399522	Certificate TypeCertificate of Analysis	Date07/08/2024	Catalog Number21857
Lot NumberZE368692	Certificate TypeCertificate of Analysis	Date04/06/2024	Catalog Number21857
Lot NumberZC350351	Certificate TypeCertificate of Analysis	Date16/04/2024	Catalog Number21857

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