missing translation for 'onlineSavingsMsg'
Learn More

Gibco™ Human EGF, Animal-Free Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Brand:  Gibco™ AF-100-15-500UG

180.42 EUR valid until 2024-12-20
Use promo code "21651" to get your promotional price.


 View more versions of this product

Product Code. 17853743

  • 194.00 € / 500µg

Please to purchase this item. Need a web account? Register with us today!

Edge
Explore more special offers
This item is not returnable. View return policy

Description

Description

EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

P01133
protein with no preservative
6.2
500 μg
-20°C
<0.1 EU/μg
EGF
Unconjugated
NSDSECPLSH DGYCLHDGVC MYIEALDKYA CNCVVGYIGE RCQYRDLKWW ELR
≥ 98% by SDS-PAGE gel and HPLC analyses.
Functional Assay
1950
Human EGF, Animal-Free
E. coli
RUO
AI790464; beta-urogastrone; EGF; Epidermal growth factor; epidermal growth factor (beta-urogastrone); epidermal growth factor precursor; H-EGF; HOMG4; Pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF); sb:eu639; URG; Urogastrone
Human
Recombinant
Lyophilized
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers