missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Gibco™ Human EGF, Animal-Free Recombinant Protein, PeproTech®
E. coli Recombinant Protein
Brand: Gibco™ AF-100-15-500UG
180.42 EUR valid until 2024-12-20
Use promo code "21651" to get your promotional price.
This item is not returnable.
View return policy
Description
EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.Specifications
P01133 | |
protein with no preservative | |
6.2 | |
500 μg | |
-20°C | |
<0.1 EU/μg | |
EGF | |
Unconjugated | |
NSDSECPLSH DGYCLHDGVC MYIEALDKYA CNCVVGYIGE RCQYRDLKWW ELR | |
≥ 98% by SDS-PAGE gel and HPLC analyses. |
Functional Assay | |
1950 | |
Human EGF, Animal-Free | |
E. coli | |
RUO | |
AI790464; beta-urogastrone; EGF; Epidermal growth factor; epidermal growth factor (beta-urogastrone); epidermal growth factor precursor; H-EGF; HOMG4; Pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF); sb:eu639; URG; Urogastrone | |
Human | |
Recombinant | |
Lyophilized |