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Thermo Scientific™ DTME (dithiobismaleimidoethane)

Crosslink sulfhydryls to sulfhydryls (cysteine residues) with this long, cleavable crosslinker composed of maleimide groups and 11-atom (13.3A) disulfide spacer arm.

Brand: Thermo Scientific™ 22335

Product Code. 10371314

389.00 € / 50mg

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Description

Thermo Scientific™ Pierce DTME is a mid-length, maleimide crosslinker for reversible covalent conjugation between sulfhydryl groups (e.g., protein or peptide cysteines) by reduction of the disulfide bond in the center of the spacer arm.

Highlights:

Cleavable by reducing agents
Reactive groups: maleimide (homobifunctional)
Reactive toward: sulfhydryl groups

Specifications

Chemical Reactivity	Sulfhydryl-Sulfhydryl
Description	DTME
PEGylated	No
Content And Storage	Upon receipt store desiccated at 4°C.
Shipping Condition	Ambient
Labeling Method	Chemical Labeling
Reactive Moiety	Maleimide
Form	Solid
Solubility	DMF, DMSO
Water Soluble	No

Cleavable	By Thiols
Molecular Weight (g/mol)	312.36
Spacer Arm Length	13.3 Å
Cell Permeability	Yes
Product Line	Pierce™
Crosslinker Type	Homobifunctional
Spacer	Medium (10 to 30 Å)
Quantity	50 mg
Format	Standard
Product Type	Crosslinker

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Safety and Handling

Product Identifier

DTME (dithiobismaleimidoethane)

Signal Word

Warning

Hazard Category

Acute toxicity Category 4
Serious eye damage/eye irritation Category 2
Skin corrosion/irritation Category 2
Specific target organ toxicity Category 3

Hazard Statement

H302-Harmful if swallowed.
H312-Harmful in contact with skin.
H315-Causes skin irritation.
H319-Causes serious eye irritation.
H332-Harmful if inhaled.
H335-May cause respiratory irritation.

Precautionary Statement

P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
P302+P352-IF ON SKIN: Wash with plenty of water/soap.
P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+P313-If skin irritation occurs: Get medical advice/attention.
P337+P313-If eye irritation persists: Get medical advice/attention.

Supplemental information

MIXTURE LIST-Contains : Dithio-BisMaleimidoethane

Documents

Product Information

Manuals

User Guide: DTME Version: Jan. 2015 File size: 58.9 kB

Certificates

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Lot Number

5 results found

Lot Number	Certificate Type	Date	Catalog Number
Lot NumberZJ391767	Certificate TypeCertificate of Analysis	Date16/10/2024	Catalog Number22335
Lot NumberSPECS	Certificate TypeCertificate of Analysis	Date15/10/2024	Catalog Number22335
Lot NumberYL384136	Certificate TypeCertificate of Analysis	Date25/01/2024	Catalog Number22335
Lot NumberYB358213	Certificate TypeCertificate of Analysis	Date28/02/2023	Catalog Number22335
Lot NumberWJ320554	Certificate TypeCertificate of Analysis	Date29/10/2021	Catalog Number22335

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